Switched from D2OL to Folding@home
I used to run D2ol's software app to use my computer's idle time to calculate drug vectors. They had a very cool dashboard showing which drug candidate was targeting which disease, and a list of teams that you could join for bragging rights.
Lately their data server has been non-responsive and they have not sent out any information to their users. D2OL's latest "what's new" post on their front page is from March 2004, almost 2 years ago. And their app, for some wierd reason, runs poorly on my Kubuntu installation. It is Java-based, so it is a memory and CPU hog - instead of playing nicely and relinquishing the CPU, it noticeably slows down performance, and the UI is nearly impossible to use once it starts calculating.
Report for the first 12 hours: simple to use, polite system denizen. I recommend it.